Skip to main content
. 2014 Sep 2;9(9):e105110. doi: 10.1371/journal.pone.0105110

Table 2. Number and proportion of off-label prescriptions stratified by off-label type (year 2008).

Compound class Compound All prescriptions (n) Off-label overall (n,%) Off-label due to age only (n) Off-label due to indication only (n) Off-label due to age and indication (n)
Inhaled SABA Salbutamol 159,655 67,084 (42.0%) 0 67,084 0
Fenoterol 1,452 383 (26.4%) 6 367 10
Terbutaline 184 34 (18.5%) 0 33 1
Inhaled SABA combination Fenoterol/Ipratropium (fixed combination) 3,998 1,722 (43.1%) 0 1,722 0
Reproterol/CGA (fixed combination) 8,729 2,538 (29.1%) 0 2,538 0
Inhaled SABA (incl. combination) Total 174,018 71,761 (41.2%) 6 71,744 11
Inhaled LABA Salmeterol 522 86 (16.5%) 9 75 2
Formoterol 4,931 839 (17.0%) 88 730 21
Inhaled LABA/ICS Salmeterol/Fluticasone (fixed combination) 27,600 4,278 (15.5%) 368 3,734 176
Formoterol/Beclomethasone (fixed combination) 2,515 848 (33.7%) 11 827 10
Formoterol/Budesonide (fixed combination) 13,833 2,584 (18.7%) 113 2,412 59
Inhaled LABA (incl. combination) Total 49,401 8,635 (17.5%) 589 7,778 268
SAMA Ipratropium 21,822 10,910 (50.0%) 0 10,910 0
LAMA Tiotropium 97 96 (99.0%) 9 11 76
Muscarinic antagonists (SAMA & LAMA) Total 21,919 11,006 (50.2%) 9 10,921 76
Inhaled bronchodilative drugs (SABA, LABA, SAMA, LAMA [incl. combination]) Total 245,338 91,402 (37.3%) 604 90,443 355
ICS Budesonide 42,067 3,166 (7.5%) 0 3,166 0
Beclomethasone 24,185 1,922 (7.9%) 0 1,922 0
Fluticasone 17,097 5,360 (31.4%) 1,917 2,370 1,073
Ciclesonide 326 110 (33.7%) 35 60 15
ICS total 83,675 10,558 (12.6%) 1,952 7,518 1,088
Oral B2A Salbutamol 19,475 5,544 (28.5%) 0 5,544 0
Terbutaline 6,940 2,012 (29.0%) 0 2,012 0
Tulobuterol 1,201 330 (27.5%) 32 292 6
Clenbuterol 113 67 (59.3%) 0 67 0
Oral B2A combination Clenbuterol/Ambroxol (fixed combination) 91,385 18,897 (20.7%) 0 18,897 0
Oral B2A (incl. combination) total 119,114 26,850 (22.5%) 32 26,812 6
Others Theophylline 1,184 451 (38.1%) 7 419 25
Montelukast 33,501 12,826 (38.3%) 304 11,831 691
Cromoglicic acid 5,087 3,247 (63.8%) 110 2,724 413
Others Total 39,772 16,524 (41.5%) 421 14,974 1,129
All drugs Total 487,899 145,334 (29.8%) 3,009 139,747 2,578

SABA: Short-acting beta-2-agonist, CGA: Cromoglicic acid, LABA: Long-acting beta-2-agonist, ICS: Inhaled corticosteroid, SAMA: Short-acting muscarinic antagonist, LAMA: Long-acting muscarinic antagonist, B2A: Beta-2-agonist.