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. 1975 Jun;11(6):1306–1311. doi: 10.1128/iai.11.6.1306-1311.1975

Immunological Sequelae of Trichinella spiralis Infection in Mice: Effect on the Antibody Responses to Sheep Erythrocytes and Japanese B Encephalitis Virus

A S Lubiniecki a,1, R H Cypess a
PMCID: PMC415216  PMID: 166916

Abstract

Immunosuppression of the antibody response to Japanese B encephalitis (JBE) virus and sheep erythrocytes (SRBC) was observed in mice infected with Trichinella spiralis. This suppression was paralleled by the presence of fewer antibody-forming cells to SRBC in the spleens of parasitized mice. Both primary and secondary complement-fixing antibody responses to JBE virus were suppressed, but the development of immunological memory was not affected. Parasitized mice demonstrated a normal blastogenic response to phytohemagglutinin and normal serum clearance rate of injected 125I-labeled immunoglobulin G2b, although the size of the extravascular fluid compartment was significantly increased. The data presented here and in previous reports suggest that sequential antigenic competition is a possible explanation for the humoral immunosuppression to heterologous antigens caused by T. spiralis infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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