Fig. 4.
The effect of the GPR40 agonist, GW9508 (GW) on calcium levels in nodose neurons. A: representative trace from an LA (10 μM) and GW (40 μM) responsive neuron. B: average calcium increase induced by LA and GW in LA and GW responsive neurons (n = 23 and 26, respectively). C: number of neurons responsive to LA and GW. Symbols on the x-axis indicate responsiveness (+) or unresponsiveness (−) to LA (top line) or GW (bottom line) only and those responsive to both LA and GW. Most LA-responsive neurons (about 20% of the 96 neurons tested) were also responsive to GW. *Occurrence of GW and LA responsiveness significantly overlapped (P < 0.001, χ2 analysis).