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. Author manuscript; available in PMC: 2014 Sep 2.
Published in final edited form as: Leuk Lymphoma. 2014 Feb 4;55(9):1980–1992. doi: 10.3109/10428194.2013.855307

Figure 2. The BCL-2 protein family.

Figure 2

The BCL-2 proteins share a BCL-2 homology (BH) domain. The antiapoptotic BCL-2 proteins (BCL-2, BCL-XL, BCL-w, MCL-1, BCL2A1 and BCL-B) have four BH domains and the proapoptotic BAK, BAX and BOK proteins have three BH domains, while the proapoptotic BIM, BID, PUMA, NOXA, BAD, BMF, BIK, and HRK proteins have only BH3 domain. The location of the transmembrane (TM) domain is indicated in the figure. Of the BH3-only proteins, only BIK and HRK have a TM domain. The panels representing the three groups of proteins are not drawn to scale, and the amino acid lengths shown represent the canonical size.