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. 2014 Sep 2;9(9):e106519. doi: 10.1371/journal.pone.0106519

Figure 2. ESAT-6/CFP10-specific IFN-γ responses of cattle after revaccination and Mycobacterium bovis challenge.

Figure 2

Mean IFN-γ responses for groups of cattle following revaccination and subsequent challenge with M. bovis at 23 weeks after revaccination. Non-vaccinated cattle (•, n = 17); BCG-vaccinated, but not revaccinated (○, BCG once group, n = 16); BCG-vaccinated and revaccinated 2 years later with BCG (▾, BCG/BCG group, n = 15); BCG-vaccinated and revaccinated 2 years later with TB biobeads displaying mycobacterial proteins, ESAT-6 and Ag85A (Δ, BCG/Biobeads group, n = 15), BCG-vaccinated and revaccinated 2 years later with M. bovis culture filtrate protein vaccine (▪, BCG/CFP group, n = 16). Results expressed as IFN-γ ESAT-6/CFP10 (pg/ml) minus Nil (PBS) pg/ml. Arrow indicated challenge with M. bovis at 23 weeks after revaccination and error bar represented SEM. Significant difference from the non-vaccinated group was denoted by **p<0.01.