Table 1. Components of nuclear protein inclusions with listing of their histochemical and biophysical amyloid features.

Amyloid component	IHC	NI	PolyQ- induced	PolyQ disease	Animal model	Cell culture	CR/ThT	CR bi	AP	anti Aβ	Reference
huntingtin	●	●	●	●	●	●	●	●			31, 32, 71, 72
ubiquitin	●	●	●	●	●	●					31, 32, 43, 72
androgen receptor	●	●	●	●	●	●					36, 73
ataxin-1	●	●	●	●	●	●					38, 74
20S proteasome	●	●	●	●	●						38, 41
HDJ-2/HSDJ	●	●	●	●	●						38
HSP-70	●	●	●	●		●					38, 43, 75
p53		●	●			●					43
mdm-2		●	●			●					43
TATA binding protein	●	●	●	●	●	●					43, 72, 76, 77
NPC proteins	●	●	●			●					43
ataxin-3	●	●	●	●	●						78, 79
atrophin-1	●	●	●	●							80
CREB binding protein	●	●	●	●		●					45, 80
PML	●	●	●	●	●	●					34, 74, 80
SUMO-1	●	●	●	●	●	●					34, 81
SUMO-2	●	●	●	●	●	●					81
ataxin-7	●	●	●	●	●	●					81
p80 coilin	●	●	●	●		●					34, 74
histone H3	●	●	●			●					82
hnRNP F/H	●	●	●			●					82
smn1		●				●			●	●	15
gemin4		●				●			●	●	15
SR140		●				●			●	●	15
WDR3		●				●			●	●	15
ranBP1		●				●			●	●	15
laminB1		●				●			●	●	15
NuMA		●				●			●	●	15
nuclear amyloid structure	●	●			●	●	●		●	●	24, 25, 40

Anti Aβ, detection by amyloid specific antibodies; AP, amyloid peptide binding; CR bi, Congo red birefringence; CR/ThT, Congo red and/or Thioflavin T binding; IHC, nuclear inclusions defined by immunohistochemistry; NI, nuclear inclusion.