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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Eur J Immunol. 2013 Oct;43(10):2526–2533. doi: 10.1002/eji.201343833

Figure 2. C. albicans directly stimulates HSPCs to induce myelopoiesis.

Figure 2

C. albicans interacts in vitro with mouse HSPCs from the most quiescent HSCs (LT-HSCs) to the lineage-committed progenitors (CMPs and GMPs, top), inducing the differentiation of these cells towards the myeloid lineage in a TLR2-dependent manner. C. albicans also induces TLR2- and Dectin-1-dependent production of moDCs by Lin− HSPCs in vitro, and TLR2-dependent macrophage production by transplanted LKS+ and Lin− cells upon C. albicans infection in vivo (bottom). Dectin-1 activation also promotes monocyte differentiation to macrophages and moDCs (bottom).