Table 1.
mRNA expression profiles of hypoxia-related genes in MDA-MB-231 wt, EV and dnHIF cells
| Symbol | Description | Fold up- or downregulation under hypoxia versus normoxia | ||
|---|---|---|---|---|
| MDA-MB-231 wt | MDA-MB-231 EV | MDA-MB-231 dnHIF | ||
| ADM | Adrenomedullin | 2.18 | 1.73 | -1.00 |
| ANGPTL4 | Angiopoetin-like 4 | 2.72 | 3.19 | 2.65 |
| BHLHE40 | Basic helix-loop-helix family, member e40 | 1.56 | 2.18 | 2.16 |
| CASP1 | Caspase-1 | -1.44 | -2.03 | -1.67 |
| HIF-1α | Hypoxia inducible factor 1, alpha subunit | -2.61 | -3.26 | -2.29 |
| HIF-3α | Hypoxia inducible factor 3, alpha subunit | -2.25 | -1.71 | -1.68 |
| IPCEF1 | Interaction protein for cytohesin exchange factors 1 | -3.75 | -1.51 | 4.48 |
| LCT | Lactase | -1.02 | -2.39 | -1.73 |
| LEP | Leptin | -1.96 | -1.04 | -4.06 |
| MT3 | Metallothionein 3 | 1.52 | 1.06 | 2.01 |
| SLC2A4 | Solute carrier family 2 (facilitated glucose transporter), member 4 | -2.10 | -1.16 | -1.38 |
Only genes with a more than two-fold up- or downregulation under hypoxia versus normoxia are presented. (-) represents downregulation. Cells were exposed to normoxia/hypoxia for 24 h (see Methods for full details). All results are from at least 3 independent experiments.