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. 2014 Sep 3;34(36):12182–12191. doi: 10.1523/JNEUROSCI.1373-14.2014

Figure 6.

Figure 6.

Impaired eIF2B activity in oligodendrocytes had minimal effect on myelin in the CNS of adult mice. A, MBP immunostaining revealed that the degree of myelination in the cerebellum of adult PLP/Fv2E-PERK Tg/Tg mice treated with AP20187 was comparable to vehicle-treated mice. B, Western blot analysis showed that AP20187 treatment did not significantly alter the level of MBP in the brain of adult PLP/Fv2E-PERK Tg/Tg mice. C, D, EM analysis showed that AP20187 treatment significantly but moderately decreased the number of myelinated axons in the brain of adult PLP/Fv2E-PERK Tg/Tg mice. E, Quantitative EM analysis showed that AP20187 treatment did not alter the thickness of the myelin sheaths, but significantly reduced the diameter of axons in the CNS of PLP/Fv2E-PERK Tg/Tg mice; N = 4 animals. Error bars represent SD. *p < 0.05. Scale bars: A, 500 μm; C, 1 μm.