Figure 4.

Aβ-induced LTP failure is prevented by genetic removal of the α2-subunit of AMPK. A, Comparable LTP was induced by HFS in hippocampal slices from either wild-type (WT; open squares, n = 7) or AMPKα2 KO mice (gray circles, n = 7). B, HFS-induced LTP was inhibited by exogenous Aβ (dark gray squares, n = 5), but maintained in slices derived from AMPKα2 KO mice in the presence of Aβ (gray triangles, n = 5). C, Representative fEPSP traces before and after HFS for LTP experiments shown in A and B. D, Cumulative data showing mean fEPSP slopes 80 min after HFS based on LTP experiments in A and B. Unpaired independent t test; *p < 0.05.