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. 2014 Aug 11;32(26):2836–2846. doi: 10.1200/JCO.2013.53.7365

Table 1.

Major Radiosurgery Series for Nonfunctioning Pituitary Adenomas

Study Publication Year No. of Patients Mean or Median Follow-Up (months) Mean or Median Margin Dose (Gy) Radiographic Tumor Control (%)
Feigl et al19 2002 61 55.2 15 94
Sheehan et al28 2002 42 31.2 16 97.6
Wowra et al29 2002 30 57.7 16 93.3
Petrovich et al26 2003 52 34 15 100
Losa et al23 2004 54 41.1 16.6 96.3
Muacevic et al25 2004 51 21.7 16.5 95
Kajiwara et al22 2005 14 32.1 12.6 92.9
Picozzi et al27 2005 51 40.6 16.5 96.1
Iwai et al21 2005 28 36.4 12.3 93
Mingione et al24 2006 100 46.4 18.5 92.2
Voges et al41 2006 37 56.6 13.4 100
Liscak et al36 2007 140 60 20 100
Pollock et al38 2008 62 64 16 96.8
Hoybye et al20 2009 23 78 20 100
Kobayashi et al35 2009 71 50.2 NR 96.7
Castro et al30 2010 14 42 12.5 100
Hayashi et al33 2010 43 36 18.2 100
Gopalan et al32 2011 48 95 18.4 83
Iwata et al34 2011 100 33 21 Gy/3 fr, 25 Gy/5 fr 98
Park et al37 2011 125 62 13 90
El-Shehaby et al31 2012 21 44 12 85
Runge et al39 2012 65 83 13 98.3
Starke et al40 2012 140 50.4 18 90
Wilson et al42 2012 51 50 14 100
Sheehan et al43 2013 512 36 16 93

Abbreviations: fr, fraction; NR, not reported.