Table 1.

Radiation Therapy Trials in Which QOL Instruments Were Prognostic for Outcome

Reference	No. of Patients	Cancer Type	Treatment	PRO-Related Conclusions
De Boer et al2	133	H&N	Sx, RT	Factors predicting for better LRC and OS were high level of perceived self-efficacy, low score on uncertainty handling illness, more psychosocial complaints
de Graeff et al3	208	H&N	Sx, RT	Patients with cognitive score of 100 on EORTC QLQ-C30 had greater OS and LRC than those with a score of < 100
Fang et al4	102	H&N	RT	High pretreatment baseline fatigue score predicted for significantly poorer 2-year OS. A 10-point increase in score resulted in 17% reduction in likelihood of survival
Kaasa et al5	102	NSCLC	CT, RT	General symptoms and psychosocial well being predicted for OS
Langendijk et al6	198	NSCLC	RT	Baseline global QOL scores significantly predicted for OS in patients with pathologically involved lymph nodes
Montazeri et al7	129	Lung		Pretreatment global QOL was a significant predictor of survival
Siddiqui et al8	1,093	H&N	RT, RT + CT	FACT H&N and the functional well-being component of FACT-G predicted significantly for LRC
Movsas et al9	239	NSCLC	RT + CT	Baseline global QOL predicted for OS. A 10-point increase in baseline score decreased hazard of death by 10%

Abbreviations: CT, chemotherapy; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30; FACT-G, Functional Assessment of Cancer Therapy–General; FACT-H&N, FACT–Head and Neck; H&N, head and neck; LRC, locoregional control; NSCLC, non–small-cell lung cancer; OS, overall survival; QOL, quality of life; RT, radiation therapy; Sx, surgery.