Table 1.
Cell-Cycle Distribution Induced by Berberine and d-Limonene Alone and in Combination in MGC803 Cells
Cell cycle (%) | ||||
---|---|---|---|---|
Treatment | Time (h) | G0/G1 | S | G2/M |
Untreated control | 0 | 41.64±2.25 | 32.38±1.18 | 25.98±3.43 |
Berberine | 24 | 48.61±0.91a | 28.3±1.48a | 23.09±2.40 |
36 | 47.69±0.92a | 27.77±1.38a | 24.54±2.31 | |
48 | 46.49±2.34a | 27.88±0.27a | 25.63±2.22 | |
d-Limonene | 24 | 46.71±0.70a | 27.22±0.11a | 26.07±0.81 |
36 | 35.95±4.44a | 27.92±3.09a | 33.13±2.88a | |
48 | 58.81±4.15a | 12.84±0.78a | 28.36±3.36a | |
Berberine+d-limonene | 24 | 66.58±0.92abc | 25.94±2.37a | 8.38±1.53abc |
36 | 49.96±1.36ac | 0abc | 50.04±1.36abc | |
48 | 62.19±1.49ab | 0.11±0.19abc | 37.7±1.31abc |
Significantly different compared with the control group.
Significantly different compared with berberine group.
Significantly different compared with d-limonene group, P<.05.