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. Author manuscript; available in PMC: 2014 Sep 3.
Published in final edited form as: Genomics. 2009 Mar 28;94(1):20–31. doi: 10.1016/j.ygeno.2009.03.003

Table 1.

A Top 50 genes that were most significantly increased in expression in DCM.
Probe ID UniGene ID Symbol Gene_name FCa
184159 Hs.75640 NPPA natriuretic peptide precursor A 24.27
101060 Hs.8364 PDK4 pyruvate dehydrogenase kinase, isozyme 4 16.44
127385 Hs.461571 MLYCD malonyl-CoA decarboxylase 9.23
212992 Hs.356190 UBB ubiquitin B 7. 21
115431 Hs.25829 RASD1 RAS, dexamethasone-induced 1 7.18
199204 Hs.567501 AIG1 androgen-induced 1 7.1 2
119696 Hs.3192 PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 7.03
168813 Hs.17860 OGDHL oxoglutarate dehydrogenase-like 6.94
11174 8 Hs.501280 HTRA1 HtrA serine peptidase 1 6.87
117167 Hs.204041 AHSA1 AHA1, activator of heat shock 90 kDa protein ATPase homolog 1 (yeast) 6.73
118421 Hs.480085 TNNI3K TNNI3 interacting kinase 6.68
146066 Hs.494186 C9orf95 chromosome 9 open reading frame 95 5.85
211439 Hs.500756 GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 5.83
162178 Hs.512670 BCAT2 branched chain aminotransferase 2, mitochondrial 5.71
209321 Hs.518834 B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 5.54
122333 Hs.529276 FLJ21901(FASTKD1) 5.46
112942 Hs.479491 C1orf139(GPR177) chromosome 1 open reading frame 139 5.46
161710 Hs.924 CRYM crystallin, mu 5.31
205457 Hs.424932 AIFM1 programmed cell death 8 (apoptosis-inducing factor) 5.25
146299 Hs.567431 SIRT5 sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) 5.24
214987 Hs.12084 TUFM Tu translation elongation factor, mitochondrial 5.06
214864 Hs.184492 ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 4.98
200831 Hs.499916 FAM48A family with sequence similarity 48, member A 4.93
158867 Hs.523454 TPP1 tripeptidyl peptidase I 4.92
155357 Hs.183428 SSPN sarcospan (Kras oncogene-associated gene) 4.91
202365 Hs.524234 FNDC5 fibronectin type III domain containing 5 4.87
115589 Hs.460184 MCM4 MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) 4.79
210061 Hs.486596 NHSL1 NHS-like 1 4.79
195766 Hs.155729 ETFDH electron-transferring-flavoprotein dehydrogenase 4.77
182995 Hs.379636 UNC45B unc-45 homolog B (C. elegans) 4.76
124513 Hs.172510 C1orf88 chromosome 1 open reading frame 88 4.74
217302 Hs.524750 NUP98 nucleoporin 98 kDa 4.56
202618 Hs.8526 B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 4.51
158513 Hs.432121 PRDX2 peroxiredoxin 2 4.43
102257 Hs.508848 HNRPC(HNRNPC) heterogeneous nuclear ribonucleoprotein C (C1/C2) 4.21
190596 Hs.529353 ACSS1 acyl-CoA synthetase short-chain family member 1 4.17
213069 Hs.279709 TRIM63 tripartite motif-containing 63 4.16
107417 Hs.13434 ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 4.05
115807 Hs.76394 ECHS1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial 4.05
100079 Hs.113684|Hs.567290 HSPD1 heat shock 60 kDa protein 1 (chaperonin) 4.04
218816 Hs.101174|Hs.569810 MAPT microtubule-associated protein tau 4.00
203523 Hs.79064 DHPS deoxyhypusine synthase 3.98
134459 Hs.508720 RAB20 RAB20, member RAS oncogene family 3.95
179728 Hs.472737 TOP1 topoisomerase (DNA) I 3.88
101676 Hs.7296 C17orf71 chromosome 17 open reading frame 71 3.88
169529 Hs.555973 MRPS25 mitochondrial ribosomal protein S25 3.79
169750 Hs.183070 STAMBP STAM binding protein 3.73
144908 Hs.474982 ACO2 aconitase 2, mitochondrial 3.71
195306 Hs.157106 JMJD2C jumonji domain containing 2C 3.65
162286 Hs.534540 ZFAND2B zinc finger, AN1-type domain 2B 3.65
B Top 50 gene that were most significantly decreased in expression in DCM.
Probe ID UniGene ID Gene symbol Gene_name FCa
123450 Hs.165258 NR4A2 nuclear receptor subfamily 4, group A, member 2 −4.83
221732 Hs.161851 KCNQ2 potassium voltage-gated channel, KQT-like subfamily, member 2 −4.78
179577 Hs.535591| LOC375251 −4.72
652781 Hs.388313 MIRHG2 −4.67
155850 Hs.81256 S100A4 S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) −4.39
215752 Hs.65641 SAMD9 sterile alpha motif domain containing 9 −4.29
209986 Hs.517307 MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) −4.25
162446 Hs.275086|Hs.380135 PRDM10|FABP1 PR domain containing 10|fatty acid binding protein 1, liver −4.23
217544 Hs.352220 MGC23270 −4.23
207085 Hs.445496 MAP3K9 mitogen-activated protein kinase kinase kinase 9 −4.11
171927 Hs.154057 MMP19 matrix metallopeptidase 19 −4.11
159046 Hs.81337 LGALS9 lectin, galactoside-binding, soluble, 9 (galectin 9) −4.10
200670 Hs.500066 TADA2L transcriptional adaptor 2 (ADA2 homolog, yeast)-like −4.03
132165 Hs.533471 IFNA13 interferon, alpha 13 −4.02
224571 Hs.516971 FKHL18(FOXS1) forkhead-like 18 (Drosophila) −4.02
145309 Hs.532345 ZFYVE9 zinc finger, FYVE domain containing 9 −4.02
206143 Hs.437877 AMHR2 anti-Mullerian hormone receptor, type II −3.96
223807 Hs.252543 IKIP −3.90
691815 Hs.196484 C1orf178 chromosome 1 open reading frame 178 −3.86
223796 Hs.190877 C9orf66 chromosome 9 open reading frame 66 −3.80
102968 KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog −3.69
158586 Hs.317659 DPPA4 developmental pluripotency associated 4 −3.66
141970 Hs.238889 UNC5D unc-5 homolog D (C. elegans) −3.64
126259 Hs.567576 RNF219 chromosome 13 open reading frame 7 −3.60
114684 Hs.506829 LASS6 LAG1 longevity assurance homolog 6 (S. cerevisiae) −3.58
107450 Hs.448664 TMEM80 transmembrane protein 80 −3.57
129347 Hs.381312 OR2K2 olfactory receptor, family 2, subfamily K, member 2 −3.51
177348 Hs.159628 SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 −3.45
141595 Hs.164797 TREML2 triggering receptor expressed on myeloid cells-like 2 −3.39
127023 Hs.554529 OR4A15 olfactory receptor, family 4, subfamily A, member 15 −3.39
145949 Hs.371987 NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive −3.37
171525 Hs.821 BGN biglycan −3.32
169674 Hs.131151 PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 −3.32
102572 Hs.279209 CCDC41 coiled-coil domain containing 41 −3.28
224005 Hs.73680|Hs.470488 CMYA3(XIRP2) cardiomyopathy associated 3 −3.27
111499 Hs.434720|Hs.55016 EPS8L2 EPS8-like 2 −3.24
198318 Hs.201641 BASP1 brain abundant, membrane attached signal protein 1 −3.21
110723 Hs.549368 LOC439913 −3.19
134951 Hs.106511 PCDH17 protocadherin 17 −3.18
212531 Hs.69360 KIF2C kinesin family member 2C −3.10
194003 Hs.172928 COL1A1 collagen, type I, alpha 1 −3.08
171591 Hs.552755 LOC255025 −3.08
165806 Hs.534293 SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 −3.05
195643 Hs.167017 GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 −3.02
167343 Hs.576884|Hs.118161 C10orf11 chromosome 10 open reading frame 11 −3.01
180037 Hs.76364 AIF1 allograft inflammatory factor 1 −3.00
143136 Hs.333274 CALN1 calneuron 1 −2.99
133640 Hs.302346 FLJ13391(FAM176A) −2.98
230512 HDAC2 histone deacetylase 2 −2.97
135102 Hs.517941 HYPB(SETD2) −2.97
a

FC was calculated between the mean values of control and DCM.

a

FC was calculated between the mean values of control and DCM.