Table 1.
A Top 50 genes that were most significantly increased in expression in DCM. | ||||
---|---|---|---|---|
Probe ID | UniGene ID | Symbol | Gene_name | FCa |
184159 | Hs.75640 | NPPA | natriuretic peptide precursor A | 24.27 |
101060 | Hs.8364 | PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 16.44 |
127385 | Hs.461571 | MLYCD | malonyl-CoA decarboxylase | 9.23 |
212992 | Hs.356190 | UBB | ubiquitin B | 7. 21 |
115431 | Hs.25829 | RASD1 | RAS, dexamethasone-induced 1 | 7.18 |
199204 | Hs.567501 | AIG1 | androgen-induced 1 | 7.1 2 |
119696 | Hs.3192 | PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) | 7.03 |
168813 | Hs.17860 | OGDHL | oxoglutarate dehydrogenase-like | 6.94 |
11174 8 | Hs.501280 | HTRA1 | HtrA serine peptidase 1 | 6.87 |
117167 | Hs.204041 | AHSA1 | AHA1, activator of heat shock 90 kDa protein ATPase homolog 1 (yeast) | 6.73 |
118421 | Hs.480085 | TNNI3K | TNNI3 interacting kinase | 6.68 |
146066 | Hs.494186 | C9orf95 | chromosome 9 open reading frame 95 | 5.85 |
211439 | Hs.500756 | GOT1 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 5.83 |
162178 | Hs.512670 | BCAT2 | branched chain aminotransferase 2, mitochondrial | 5.71 |
209321 | Hs.518834 | B3GALT2 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 | 5.54 |
122333 | Hs.529276 | FLJ21901(FASTKD1) | 5.46 | |
112942 | Hs.479491 | C1orf139(GPR177) | chromosome 1 open reading frame 139 | 5.46 |
161710 | Hs.924 | CRYM | crystallin, mu | 5.31 |
205457 | Hs.424932 | AIFM1 | programmed cell death 8 (apoptosis-inducing factor) | 5.25 |
146299 | Hs.567431 | SIRT5 | sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) | 5.24 |
214987 | Hs.12084 | TUFM | Tu translation elongation factor, mitochondrial | 5.06 |
214864 | Hs.184492 | ELAVL1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 4.98 |
200831 | Hs.499916 | FAM48A | family with sequence similarity 48, member A | 4.93 |
158867 | Hs.523454 | TPP1 | tripeptidyl peptidase I | 4.92 |
155357 | Hs.183428 | SSPN | sarcospan (Kras oncogene-associated gene) | 4.91 |
202365 | Hs.524234 | FNDC5 | fibronectin type III domain containing 5 | 4.87 |
115589 | Hs.460184 | MCM4 | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 4.79 |
210061 | Hs.486596 | NHSL1 | NHS-like 1 | 4.79 |
195766 | Hs.155729 | ETFDH | electron-transferring-flavoprotein dehydrogenase | 4.77 |
182995 | Hs.379636 | UNC45B | unc-45 homolog B (C. elegans) | 4.76 |
124513 | Hs.172510 | C1orf88 | chromosome 1 open reading frame 88 | 4.74 |
217302 | Hs.524750 | NUP98 | nucleoporin 98 kDa | 4.56 |
202618 | Hs.8526 | B3GNT6 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 | 4.51 |
158513 | Hs.432121 | PRDX2 | peroxiredoxin 2 | 4.43 |
102257 | Hs.508848 | HNRPC(HNRNPC) | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 4.21 |
190596 | Hs.529353 | ACSS1 | acyl-CoA synthetase short-chain family member 1 | 4.17 |
213069 | Hs.279709 | TRIM63 | tripartite motif-containing 63 | 4.16 |
107417 | Hs.13434 | ATPAF2 | ATP synthase mitochondrial F1 complex assembly factor 2 | 4.05 |
115807 | Hs.76394 | ECHS1 | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 4.05 |
100079 | Hs.113684|Hs.567290 | HSPD1 | heat shock 60 kDa protein 1 (chaperonin) | 4.04 |
218816 | Hs.101174|Hs.569810 | MAPT | microtubule-associated protein tau | 4.00 |
203523 | Hs.79064 | DHPS | deoxyhypusine synthase | 3.98 |
134459 | Hs.508720 | RAB20 | RAB20, member RAS oncogene family | 3.95 |
179728 | Hs.472737 | TOP1 | topoisomerase (DNA) I | 3.88 |
101676 | Hs.7296 | C17orf71 | chromosome 17 open reading frame 71 | 3.88 |
169529 | Hs.555973 | MRPS25 | mitochondrial ribosomal protein S25 | 3.79 |
169750 | Hs.183070 | STAMBP | STAM binding protein | 3.73 |
144908 | Hs.474982 | ACO2 | aconitase 2, mitochondrial | 3.71 |
195306 | Hs.157106 | JMJD2C | jumonji domain containing 2C | 3.65 |
162286 | Hs.534540 | ZFAND2B | zinc finger, AN1-type domain 2B | 3.65 |
B Top 50 gene that were most significantly decreased in expression in DCM. | ||||
---|---|---|---|---|
Probe ID | UniGene ID | Gene symbol | Gene_name | FCa |
123450 | Hs.165258 | NR4A2 | nuclear receptor subfamily 4, group A, member 2 | −4.83 |
221732 | Hs.161851 | KCNQ2 | potassium voltage-gated channel, KQT-like subfamily, member 2 | −4.78 |
179577 | Hs.535591| | LOC375251 | −4.72 | |
652781 | Hs.388313 | MIRHG2 | −4.67 | |
155850 | Hs.81256 | S100A4 | S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) | −4.39 |
215752 | Hs.65641 | SAMD9 | sterile alpha motif domain containing 9 | −4.29 |
209986 | Hs.517307 | MX1 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | −4.25 |
162446 | Hs.275086|Hs.380135 | PRDM10|FABP1 | PR domain containing 10|fatty acid binding protein 1, liver | −4.23 |
217544 | Hs.352220 | MGC23270 | −4.23 | |
207085 | Hs.445496 | MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | −4.11 |
171927 | Hs.154057 | MMP19 | matrix metallopeptidase 19 | −4.11 |
159046 | Hs.81337 | LGALS9 | lectin, galactoside-binding, soluble, 9 (galectin 9) | −4.10 |
200670 | Hs.500066 | TADA2L | transcriptional adaptor 2 (ADA2 homolog, yeast)-like | −4.03 |
132165 | Hs.533471 | IFNA13 | interferon, alpha 13 | −4.02 |
224571 | Hs.516971 | FKHL18(FOXS1) | forkhead-like 18 (Drosophila) | −4.02 |
145309 | Hs.532345 | ZFYVE9 | zinc finger, FYVE domain containing 9 | −4.02 |
206143 | Hs.437877 | AMHR2 | anti-Mullerian hormone receptor, type II | −3.96 |
223807 | Hs.252543 | IKIP | −3.90 | |
691815 | Hs.196484 | C1orf178 | chromosome 1 open reading frame 178 | −3.86 |
223796 | Hs.190877 | C9orf66 | chromosome 9 open reading frame 66 | −3.80 |
102968 | KRAS | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | −3.69 | |
158586 | Hs.317659 | DPPA4 | developmental pluripotency associated 4 | −3.66 |
141970 | Hs.238889 | UNC5D | unc-5 homolog D (C. elegans) | −3.64 |
126259 | Hs.567576 | RNF219 | chromosome 13 open reading frame 7 | −3.60 |
114684 | Hs.506829 | LASS6 | LAG1 longevity assurance homolog 6 (S. cerevisiae) | −3.58 |
107450 | Hs.448664 | TMEM80 | transmembrane protein 80 | −3.57 |
129347 | Hs.381312 | OR2K2 | olfactory receptor, family 2, subfamily K, member 2 | −3.51 |
177348 | Hs.159628 | SERPINA4 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 | −3.45 |
141595 | Hs.164797 | TREML2 | triggering receptor expressed on myeloid cells-like 2 | −3.39 |
127023 | Hs.554529 | OR4A15 | olfactory receptor, family 4, subfamily A, member 15 | −3.39 |
145949 | Hs.371987 | NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | −3.37 |
171525 | Hs.821 | BGN | biglycan | −3.32 |
169674 | Hs.131151 | PSMD9 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 | −3.32 |
102572 | Hs.279209 | CCDC41 | coiled-coil domain containing 41 | −3.28 |
224005 | Hs.73680|Hs.470488 | CMYA3(XIRP2) | cardiomyopathy associated 3 | −3.27 |
111499 | Hs.434720|Hs.55016 | EPS8L2 | EPS8-like 2 | −3.24 |
198318 | Hs.201641 | BASP1 | brain abundant, membrane attached signal protein 1 | −3.21 |
110723 | Hs.549368 | LOC439913 | −3.19 | |
134951 | Hs.106511 | PCDH17 | protocadherin 17 | −3.18 |
212531 | Hs.69360 | KIF2C | kinesin family member 2C | −3.10 |
194003 | Hs.172928 | COL1A1 | collagen, type I, alpha 1 | −3.08 |
171591 | Hs.552755 | LOC255025 | −3.08 | |
165806 | Hs.534293 | SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | −3.05 |
195643 | Hs.167017 | GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 | −3.02 |
167343 | Hs.576884|Hs.118161 | C10orf11 | chromosome 10 open reading frame 11 | −3.01 |
180037 | Hs.76364 | AIF1 | allograft inflammatory factor 1 | −3.00 |
143136 | Hs.333274 | CALN1 | calneuron 1 | −2.99 |
133640 | Hs.302346 | FLJ13391(FAM176A) | −2.98 | |
230512 | HDAC2 | histone deacetylase 2 | −2.97 | |
135102 | Hs.517941 | HYPB(SETD2) | −2.97 |
FC was calculated between the mean values of control and DCM.
FC was calculated between the mean values of control and DCM.