Table 1. Effects of Chow, PN, and PN+BBS on the adaptive immune system.
Adaptive Immune System | PN vs Chow | PN+BBS vs PN |
---|---|---|
GALT size | ↓23 | ↓25–27 |
Peyer’s Patches lymphocytes | ↓23 | ↓26, 27 |
Lamina Propria lymphocytes | ↓23 | ↓26, 27 |
sIgA | ↓23, 24 | ↓26, 27 |
| ||
Pulmonary lymphocytes | ↓28 | |
sIgA | ↓24 | ↓27, 29 |
| ||
Salivary Gland lymphocytes | ↓30 | ↓30 |
sIgA | ↓30 | ↓30 |
| ||
Functional | ||
IgA mediated anti-viral immunity | ↓31–33 | ↓35 |
Survival after bacterial challenge | ↓34 | ↓27 |
GALT, gastrointestinal-associated lymphoid tissue; PN, parenteral nutrition; BBS, bombesin; sIgA, secretory immunoglobulin A; pIgR, polymeric immunoglobulin receptor.