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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Ann Surg. 2014 Sep;260(3):432–444. doi: 10.1097/SLA.0000000000000871

Table 4.

Mechanism of innate defense for studied antimicrobial peptides.

Antimicrobial Peptide Gram activity Mechanism Result Production
sPLA260–64 Both phospholipid-sn-2 esterase Hydrolyzes membrane phospholipids Constitutive
Lysozyme65 Both β-1,4-glycosidase Attacks peptidoglycan Constitutive
RegIII-γ66, 67 Positive only Antimicrobial C-type lectin Attacks peptidoglycan Induced
Cryptdin-446, 68 Both Alpha defensin, antimicrobial peptide Form membrane pores to promote osmotic lysis Constitutive