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. 2014 Sep;350(3):635–645. doi: 10.1124/jpet.114.216382

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Fig. 2. — Candesartan elicits modest effects on prostate cancer cellular function in vitro. In vitro effects of candesartan on prostate cancer cell migration, viability, proliferation, and apoptosis were examined. (A) Bar graph showing the effect of clinical doses of candesartan on PC3 cell apoptosis determined by the levels of cytoplasmic histone–associated DNA fragments. (B) Bar graph showing the effect of clinical doses of candesartan on PC3 cell migration. (C) Bar graph showing the effect of clinical doses of candesartan on PC3 cell proliferation determined by BrdU incorporation assay. (D) Bar graph showing the effect of clinical doses of candesartan on PC3 cell viability determined by MTT assay. Except with high concentrations, candesartan did not have any appreciable effects on the progression of prostate cancer cells. Data are presented as the mean ± S.D.