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. 2014 Sep;350(3):635–645. doi: 10.1124/jpet.114.216382

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Fig. 3. — Candesartan inhibits p-p38 MAPK activation and modulates AT1/AT2 receptor expression in PC3 cells in vitro. PC3 cells were treated with a range of clinical doses of candesartan. (A) Western blot figures showing dose-dependent decrease in p38 MAPK phosphorylation in PC3 cell lysates with no changes in the activity levels of Akt and glycogen synthase kinase (GSK) 3. (B) Bar graph showing quantification of the optical densities (OD) of Western blot protein bands showing a significant and dose-dependent decrease in p38 MAPK phosphorylation in PC3 cell lysates. (C) Bar graph showing a significant dose-dependent inhibitory effect of candesartan on AT1 receptor expression in PC3 cells. (D) Bar graph showing a significant dose-dependent effect of candesartan on enhancing AT2 receptor expression in PC3 cells. Data are presented as the mean ± S.D.