Fig. 7.

Candesartan preserves endothelial-barrier integrity via inhibiting vascular permeability. (A) Graph showing real-time changes in endothelial-barrier resistance in response to conditioned media collected from PC3 cell cultures treated with various doses of candesartan. Data show that treatment with candesartan inhibits secretion of vascular permeability stimulating growth factors in a dose-dependent manner, thereby inhibiting the ability of the tumor cell–conditioned media to induce endothelial-barrier fenestrations. (B) Graph showing real-time changes in endothelial-barrier resistance in response to topically introduced PC3 cells pretreated with various doses of candesartan for 12 hours. Candesartan did not have an appreciable effect on the invasion potential of PC3 cells except at a higher concentration. (C) Bar graph showing quantification of the endothelial-barrier resistance at 4, 6, and 8 hours postaddition of control and candesartan-treated tumor cell culture conditioned medium. Data are presented as the mean ± S.D.