Fig. 10.

Spontaneous locomotor activity (distance traveled; centimeters) of C57BL6/J mice (A) and Sprague-Dawley rats (B) during 30 minutes, expressed as a time course and the total distance traveled (insets). Mice were pretreated (p.o.) with vehicle (Veh; 1% CMC), ADX88178 (3, 10, 30, and 100 mg/kg), or baclofen (10 mg/kg). Rats were pretreated (p.o.) with vehicle (1% CMC), ADX88178 (1, 3, 10, 30, and 60 mg/kg), or baclofen (10 mg/kg). Each point represents the observed mean (±S.E.M.). ***P < 0.001 compared with the Veh group.