Fig. 2.

Open-arm entries (A and C) and time spent in open arms (seconds) (B and D) in male C57BL6/J mice (A and B) and Sprague-Dawley rats (C and D) in the EPM test. Before exposure to the maze, mice (n = 10/group) were treated p.o. with vehicle (Veh; 1% CMC), ADX88178 (1, 3, 10, 30 mg/kg), or diazepam (DZP; 1.5 mg/kg), whereas rats (n = 10/group) were treated p.o. with vehicle (1% CMC), ADX88178 (10, 30, 100 mg/kg), or DZP (3 mg/kg). Each point represents the observed mean (±S.E.M.). *P < 0.05; **P < 0.01; ***P < 0.001 compared with the corresponding Veh group.