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Open-arm entries (A) and time spent in open arms (seconds) (B) in male and female WT and mGlu4 receptor KO mice in the EPM test. Before exposure to the maze, mice (n = 24–31/genotype) were treated p.o. with vehicle (Veh; 1% CMC) or ADX88178 (ADX; 10 mg/kg). Each point represents the observed mean (±S.E.M.). *P < 0.05; **P < 0.01 compared with the corresponding Veh group.
