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Time (seconds) spent in immobility by C57BL6/J mice in the FST. Before exposure to water, animals (n = 10/group) were treated p.o. with vehicle (Veh; 1% CMC), ADX88178 (3, 10, 30, 100 mg/kg), or imipramine (IMP; 30 mg/kg). Each point represents the observed mean (±S.E.M.). **P < 0.01; ***P < 0.001 compared with the Veh group.
