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Number of DOI-induced head shakes in C57BL6/J mice (n = 10/group) that were pretreated (p.o.) with vehicle (Veh; 1% CMC), ADX88178 (3, 10, 30 mg/kg), or olanzapine (OLZ; 0.1 mg/kg) and then challenged (i.p.) with either saline (SAL) or DOI (3 mg/kg). Each point represents the observed mean (±S.E.M.). *P < 0.05; ***P < 0.001 compared with the reference (Ref) group.
