TABLE 1.
Treatment | Species | Route | Dose | n | Mean Plasma Exposure |
---|---|---|---|---|---|
mg/kg | ng/ml | ||||
EPMa | |||||
ADX88178 | Mice | p.o. | 1 | 10 | 10 |
ADX88178 | Mice | p.o. | 3 | 10 | 229 |
ADX88178 | Mice | p.o. | 10 | 10 | 1287 |
ADX88178 | Mice | p.o. | 30 | 10 | 2865 |
ADX88178 | Rats | p.o. | 10 | 10 | 1129 |
ADX88178 | Rats | p.o. | 30 | 10 | 2295 |
ADX88178 | Rats | p.o. | 100 | 10 | 3513 |
MBb | |||||
ADX88178 | Mice | p.o. | 3 | 10 | 22 |
ADX88178 | Mice | p.o. | 10 | 10 | 541 |
ADX88178 | Mice | p.o. | 30 | 10 | 1619 |
ADX88178 | Mice | p.o. | 100 | 10 | 4395 |
FSTc | |||||
ADX88178 | Mice | p.o. | 3 | 10 | 167 |
ADX88178 | Mice | p.o. | 10 | 10 | 1776 |
ADX88178 | Mice | p.o. | 30 | 10 | 2994 |
ADX88178 | Mice | p.o. | 100 | 10 | 6028 |
DOId | |||||
ADX88178 | Mice | p.o. | 3 | 8 | 33 |
ADX88178 | Mice | p.o. | 10 | 8 | 338 |
ADX88178 | Mice | p.o. | 30 | 8 | 1146 |
MK-801e | |||||
ADX88178 | Mice | p.o. | 3 | 10 | 23 |
ADX88178 | Mice | p.o. | 10 | 10 | 133 |
ADX88178 | Mice | p.o. | 30 | 10 | 624 |
CARf | |||||
ADX88178 | Rats | p.o. | 1 | 8 | 106 |
ADX88178 | Rats | p.o. | 3 | 8 | 408 |
ADX88178 | Rats | p.o. | 10 | 8 | 1273 |
ADX88178 | Rats | p.o. | 30 | 8 | 3030 |
Plasma sample taken from all ADX88178-treated animals approximately 65 minutes postadministration.
Plasma sample taken from all ADX88178-treated animals approximately 90 minutes postadministration.
Plasma sample taken from all ADX88178-treated animals approximately 66 minutes postadministration.
Plasma sample taken from all ADX88178-treated animals approximately 66 minutes postadministration.
Plasma sample taken from all ADX88178-treated animals approximately 120 minutes postadministration.
Plasma sample taken from all ADX88178-treated animals approximately 70 minutes postadministration.