TABLE 2.

MEDs in several mouse and rat efficacy tests, measured plasma concentration, and estimated CSF concentration at the end of each experiment

Test	Animal Models	Species	MED Dose	Pretreatment Time	Plasma Exposure	Plasma Exposure	CSF Exposurea	CSF Exposurea
			mg/kg	min	ng/ml	nM	ng/ml	nM
Elevated plus maze	Anxiety	Mice	3	60	229	842	49	181
Elevated plus maze	Anxiety	Rats	10b	60	1129	4145	91	335
Marble burying	Anxiety/OCD	Mice	10	60	541	1987	41	149
Forced swim test	Depression	Mice	30	60	2994	10,997	225	825
DOI-induced head twitches	Psychosis	Mice	10	60	338	1243	25	93
MK-801 hyperactivity	Psychosis	Mice	30	60	624	2293	47	172
Fear conditioning	Fear	Mice	30	60	na

na, not available.

^aThe theoretical CSF exposure is calculated from the plasma exposure using the unbound plasma protein binding values in mice (f_u = 7.5%) and in rats (f_u = 8.5%).

^bThe lowest dose tested.