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. 2014 Sep;350(3):615–623. doi: 10.1124/jpet.114.215319

Fig. 7.

Fig. 7.

Involvement of mGluR1/5, PLC, and inositol 1,4,5-trisphosphate receptors in gambierol-induced ERK1/2 +phosphorylation. (A) Representative Western blots for S-(4)-CPG (500 μM) and MTEP (1 μM) inhibition of 100 nM gambierol-induced ERK1/2 phosphorylation (p-ERK). (B) Quantification of the influence of S-(4)-CPG and MTEP on gambierol-induced ERK1/2 phosphorylation (aaP < 0.01, gambierol versus vehicle control; **P < 0.01, gambierol + inhibitor versus gambierol by analysis of variance). (C) Representative Western blots for U73122 (3 μM) and 2-APB (10 μM) inhibition of gambierol-induced ERK1/2 phosphorylation (p-ERK). (D) Quantification of the inhibition of U73122 and 2-APB on gambierol-induced ERK1/2 phosphorylation (aaP < 0.01, gambierol versus vehicle control; **P < 0.01, gambierol + inhibitor versus gambierol by analysis of variance). CPG, S-(4)-CPG; Gam, gambierol; T-ERK, total ERK.