Figure 5. Nuclear import of plasmid DNA is rate limiting for gene expression at early times after microinjection.
pGFP was microinjected into the nucleus or cytoplasm of TC7 cells at the indicated copy number per cell and assayed for gene expression at (A) 4 and 8 hours, and (B) 24 hours post-injection. Between 100 and 150 cells were injected for each concentration shown. The results shown (A and B) are representative of 4 similar experiments.