TABLE 3.
Levels of [3H]Epi and [125I] α-Bungarotoxin binding to 2% Triton X-100 extracts in the two different human brain regions
Values are the mean ± S.E.M. of the four samples in each group.
| Brain Region | [3H]Epi | [125I]-α-Bgtx |
|---|---|---|
| fmol/mg protein | ||
| Basal forebrain | 31.8 ± 8.5 | 80.7 ± 7.0 |
| Cerebellum nonsmokers | 22.5 ± 2.6 | 45.7 ± 5.1 |
| Cerebellum smokers | 39.7 ± 5.3* | 48.3 ± 6.5 |
*
P = 0.02 (significant differences in cerebellar membrane [3H]Epi binding between smokers and nonsmokers: unpaired t test). No significant difference was seen between [125I]-α-Bgtx binding levels in cerebellar samples taken from smokers versus nonsmokers, by the same measure.