Table 1.

Histological analyses and measurement of IL-6 levels in electroporated and control lungs.

Condition	DNA	time	Vascular congestion	Hyaline membranes	Alveolar infiltrates	Interstitial infiltrates	IL-6 (pg/ml)
Naïve	−		0.14 ± 0.1	0	0.43 ± 0.2	0.14 ± 0.14	29 ± 14
100 V/cm 10 ms	−	1 h	0	0	0	0.33 ± 0.33	25 ± 25
	−	24 h	0	0	0.33 ± 0.33	0.33 ± 0.33	87 ± 56
	−	72 h	0	0	0.67 ± 0.33	1 ± 0	0
200 V/cm 10 us	−	1 h	0	0	0.33 ± 0.33	0.67 ± 0.33	0
	−	24 h	0	0	0.67 ± 0.33	0.67 ± 0.33	31 ± 31
	−	72 h	0.2 ± 0.2	0	0.80 ± 0.49	1.2 ± 0.37*	19 ± 19
100 V/cm 10 ms	+	1 h	0	0	0	0.67 ± 0.33	44 ± 44
	+	24 h	0	0	1 ± 0	1.33 ± 0.33‡	132 ± 24
	+	72 h	0.33 ± 0.33	0	0.83 ± 0.39	1 ± 0.26*	73 ± 25
200 V/cm 10 us	+	1 h	0	0	0	0	22 ± 22
	+	24 h	0	0	1 ± 0	1 ± 0	0
	+	72 h	0.33 ± 0.33	0	1 ± 0.4	1.16 ± 0.33*	0
Adenovirus		72 h	1 ± 0‡	0	3 ± 0.58 ‡	2 ± 0‡	161 ± 42‡

Results are presented as mean ± sem. Scale for histopathological analysis of lung injury is from 0 (healthy) to 5 (severly injured).

^*p < 0.05 compared with naive by Mann-Whitney U-test

^‡p < 0.01 compared with naive by Mann-Whitney U-test