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. Author manuscript; available in PMC: 2014 Sep 3.
Published in final edited form as: Rev Endocr Metab Disord. 2014 Jun;15(2):137–147. doi: 10.1007/s11154-013-9280-6

Figure 1. Synergy Model of Adiponectin Receptors.

Figure 1

HMW and LMW adiponectin binding to T-cadherin leads to (a) disulfide bond cleavage producing “full-length adiponectin trimers” that bind to AdipoR2 and (b) proteolytic cleavage producing “globular adiponectin trimers” that bind to AdipoR1. T-Cadherin, AdipoR1 and AdipoR2 expression is not limited to hepatocytes.