FIGURE 1.

Regulation of plant cell fate by TCPs, WUS, and WINDs. TCPs negatively regulate meristem formation via direct activation of miRNA164 and AS1, which repress CUCs. miR319 negatively regulates expression of TCPs. WUS encodes a transcriptional repressor, but positively regulates cytokinin signaling by suppressing the expression of ARRs to maintain the stem cell population in the shoot meristem. Feedback regulation between WUS and CLVs fine-tunes the maintenance of stem cell populations and meristem size. WINDs are induced by wounding, activate cytokinin signaling, and positively regulate de-differentiation to promote callus formation in wounded tissues. Red arrows indicate positive regulation and blue lines indicate negative regulation. Solid lines indicate direct regulation and dotted lines indicate indirect regulation.