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Pathways for cleavage and release of IL-1β following stimulation by P2X7. Aggregation of the inflammasome components ① Inflammasome localized ② P2X7 activation leads to K+ efflux and loading of inflammasome components (e.g. IL-1β) and IL-1β maturation .③ Secretion of lysosome content via a P2X7 K+ efflux and increase of Ca2+ ④ Budding of microvesicles that contain some of inflammasome components (e.g. IL-1β), IL-1β maturation ⑤ Microvesicles are released into the extracellular space ⑥
