Developmental trajectory of hypothalamic, ovarian, and pancreatic differentiation in sheep, where establishment of hypophyseal portal vasculature to pituitary, appearance of LH and FSH in circulation, complete ovarian follicular differentiation, and pancreatic islet formation occurs prenatally. Abbreviations used: Hypothalamus [GnRH neurons: appearance of first GnRH immunoreactive neurons, Olf. GnRH: GnRH neurons visible in olfactory bulb, and Hyp. GnRH: appearance of GnRH neurons in the hypothalamus]; Ovary [Im: implantation]. Modified from Padmanabhan and Veiga-Lopez, 2013a.