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Refined 2 Fo– Fc maps contoured at 2.0σ (panels A, B) or 1.0σ (panels C, D) and shown in blue mesh. Myo-InsP8 molecules are shown in a stick model. The kinase domain of PPIP5K2 is shown in a transparent representation. The phosphate groups around the inositol ring are numbered. Panels A, B: PPIP5K2KD/ADP complexed with myo-InsP8 (1,5-(PP)2-InsP4 3), showing two orientations. Panels C, D: PPIP5K2KD/AMP-PNP complexed with the enantiomer 3,5-(PP)2-InsP4 (4). (PDB codes: 4Q4C and 4Q4D).
