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. Author manuscript; available in PMC: 2015 Aug 29.
Published in final edited form as: Circ Res. 2014 Aug 29;115(6):546–548. doi: 10.1161/CIRCRESAHA.114.304855

Figure.

Figure

(A) XBP1 is the Missing Link between the UPR and O-GlcNAcylation. The contributions made by Wang et al are shown in blue. (B) Proteins are glycosylated in different cell compartments. (C) A key substrate for O-GlcNAcylation, which is used by the enzyme OGT (O-GlcNAc transferase), is UDP-GlcNAc (uridine diphosphate N-acetyl glucosamine). (D) UDP-GlcNAc is generated by the hexose biosynthetic pathway (HBP). O-GlcNAc groups can be removed from proteins by OGA (O-GlcNAcase). The contributions made by Wang et al are shown in blue.