Table 2. Risk of Keratoconus as estimated by mtDNA content.
| mtDNA copy number | Controls (n=208) No. (%) | Cases (n=119) No. (%) | OR† | 95% CI | P value |
|---|---|---|---|---|---|
|
By median |
|||||
|
<1.032 |
105 (50.5) |
50 (42) |
1 |
reference |
- |
|
≥1.032 |
103 (49.5) |
69 (58) |
1.40 |
0.89 – 2.21 |
0.14 |
|
By quartiles‡ |
|||||
|
<0.871 |
64 (30.7) |
25 (21) |
1 |
reference |
- |
|
0.871–1.259 |
101 (48.5) |
50 (42) |
1.26 |
0.71 – 2.24 |
0.41 |
| >1.259 | 43 (20.7) | 44 (37) | 2.62 | 1.40 – 4.89 | 0.0025 |
† OR – unadjusted odds ratio; CI – confidence interval. ‡ first quartile (<25th percentile); inter-quartile (25th – 75th percentile); third quartile (>75th percentile).