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. 2014 Apr 30;96(2):206–213. doi: 10.1038/clpt.2014.70

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Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Organic anion–transporting polypeptide–mediated interaction between [¹¹C]glyburide and rifampicin in baboon (Papio anubis) liver. Shown are coronal positron emission tomography (PET) summation images (0–60 min) acquired after injection of [¹¹C]glyburide without (left) and with (right) i.v. pretreatment with rifampicin (8.6 mg/kg over 30 min immediately before PET). Radiation scale is expressed as standardized uptake value. After rifampicin pretreatment, the area under the liver time–activity curve (AUC_liver) was reduced by 2.7-fold and AUC_liver/AUC_plasma was reduced by 14-fold compared with baseline. PET image courtesy of N. Tournier, CEA, Service Hospitalier Frédéric Joliot, Orsay, France.