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. Author manuscript; available in PMC: 2014 Sep 3.
Published in final edited form as: Br J Haematol. 2010 Mar 1;149(2):181–194. doi: 10.1111/j.1365-2141.2010.08105.x

Figure 1.

Figure 1

A diagram illustrating the developmental switching of the β-like globin gene expression in human (left) and mouse (right). Organization of human and murine β-globin loci, consisting of the linked β-like globin genes (colored boxes), upstream DNaseI hypersensitive sites (HS, red boxes) within the locus control regions (LCR), and downstream 3′HS1, is displayed. Above the graph for the human locus the shifting sites of haematopoiesis are indicated. In the graph for the mouse locus, the content of both endogenous mouse (black straight lines) and exogenous human β-like globins (blue dashed lines) in transgenic β-globin locus mice are shown. This graph is adapted from Noordermeer and de Laat 2008.