Increased presence of Notch1 receptor, hairy and enhancer of split-1 (Hes1), and glial fibrillary acidic protein (GFAP) in the hippocampal CA3 region of temporal lobe epilepsy rats.
(A) Immunohistochemical staining for Notch1 receptor, Hes1, and GFAP in the hippocampal CA3 region of the temporal lobe epilepsy rats (× 400). Notch1 receptor, Hes1, and GFAP-positive cells are shown by arrows. (B) The intensity of staining of these proteins in the hippocampal CA3 region of temporal lobe epilepsy rats. Values are presented as mean ± SD. One-way analysis of variance was conducted to compare differences among the different groups. aP < 0.05, vs. control group, status epilepticus-free group, spontaneous recurrent seizures-free group and zileuton group; bP < 0.05, vs. status epilepticus group. I: Control group; II: status epilepticus-free group; III: status epilepticus group; IV: spontaneous recur-rent seizures-free group; V: zileuton group; VI: spontaneous recurrent seizures group.