Table 3. Clusters of ontological categories induced by different EGFR kinase inhibitors.

	Induced
	All		Kinase Inhibitors		Gefitinib		Not Gefitinib
	Enrichment Score: 7.80		Enrichment Score: 6.00		Enrichment Score: 5.51		Enrichment Score: 9.64
L	lysosome	L	lysosome		metal ion binding	L	lysosome
	Enrichment Score: 4.49		Enrichment Score: 4.47		Enrichment Score: 4.87		Enrichment Score: 6.31
L	membrane fraction	L	membrane fraction	T	negative regulation of transcription	P	protein transport
	Enrichment Score: 4.20		Enrichment Score: 4.20		Enrichment Score: 3.96		Enrichment Score: 4.40
	metal ion binding	T	negative regulation of transcription	N	nucleosome assembly	L	membrane fraction
	Enrichment Score: 3.51		Enrichment Score: 4.20		Enrichment Score: 3.60		Enrichment Score: 4.06
T	negative regulation of transcription		metal ion binding	S	Steroid hormone receptor	A	regulation of apoptosis
	Enrichment Score: 3.30		Enrichment Score: 3.47		Enrichment Score: 2.40		Enrichment Score: 3.91
A	regulation of apoptosis	S	steroid hormone receptor activity	C	cyclin-dependent protein kinase inh.	P	intracellular protein transport
	Enrichment Score: 2.86		Enrichment Score: 3.06		Enrichment Score: 2.38		Enrichment Score: 3.42
A	apoptosis	N	nucleosome assembly		Ras GTPase	L	cytoplasmic membrane-bounded ves.
	Enrichment Score: 2.82		Enrichment Score: 3.02		Enrichment Score: 2.34		Enrichment Score: 3.34
S	steroid hormone receptor activity		Furin-like cysteine rich region	E	cell projection morphogenesis	T	negative regulation of transcription
	Enrichment Score: 2.81		Enrichment Score: 2.73		Enrichment Score: 2.33		Enrichment Score: 3.14
E	primary neural tube formation	A	regulation of apoptosis		spermatogenesis	A	positive regulation of apoptosis
	Enrichment Score: 2.79		Enrichment Score: 2.47		Enrichment Score: 2.32		Enrichment Score: 2.85
A	positive regulation of cell death		Ras guanine-nucleotide exch. fact.	E	neural tube closure	A	programmed cell death
	Enrichment Score: 2.76		Enrichment Score: 2.47		Enrichment Score: 2.31		Enrichment Score: 2.78
E	cell projection morphogenesis	L	cytoplasmic vesicle		BTB/POZ fold	N	nucleosome
	Enrichment Score: 2.59		Enrichment Score: 2.36		Enrichment Score: 2.29		Enrichment Score: 2.45
	phosphoinositide 3-kinase complex	E	primary neural tube formation		Zinc finger, C2H2-type/integrase		small GTPase regulator activity
	Enrichment Score: 2.54		Enrichment Score: 2.28		Enrichment Score: 2.28		Enrichment Score: 2.31
P	protein transport	E	neuron projection development		gamete generation		ATPase activity, transmembrane movement
	Enrichment Score: 2.39		Enrichment Score: 2.20		Enrichment Score: 2.03		Enrichment Score: 2.08
	Ras guanine-nucleotide exch. factor	A	positive regulation of apoptosis	L	membrane fraction		transmembrane receptor tyrosine kinase
	Enrichment Score: 2.38		Enrichment Score: 2.05		Enrichment Score: 2.02
	Aldehyde dehydrogenase	P	intracellular protein transport	P	Protein phosphatase 2C
	Enrichment Score: 2.35		Enrichment Score: 2.04
L	cytoplasmic membrane-bounded ves.	P	protein transport
	Enrichment Score: 2.32		Enrichment Score: 2.02		Erlotinib
N	nucleosome	P	regulation of phosphorylation		Enrichment Score: 3.52
	Enrichment Score: 2.22		Enrichment Score: 2.00		SH3/SH2 adaptor activity
P	intracellular protein transport	M	regulation of cell migration		Enrichment Score: 2.73
	Enrichment Score: 2.14			P	protein transport
T	negative regulation of DNA binding				Enrichment Score: 2.64
	Enrichment Score: 2.10			N	nucleosome
E	neuron projection development				Enrichment Score: 2.53
	Enrichment Score: 2.02			A	programmed cell death
	Furin-like cysteine rich region				Enrichment Score: 2.44
	Enrichment Score: 2.00			A	regulation of apoptosis
C	cyclin-dependent protein kinase inhibitor				Enrichment Score: 2.22
					Ras guanine-nucleotide exchange factor
					Enrichment Score: 1.83
				A	induction of apoptosis

The markings are as in Table 2.