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. 2014 Sep 3;9(9):e102466. doi: 10.1371/journal.pone.0102466

Table 4. Specific clusters of ontological categories regulated by all kinase inhibitors.

Suppressed 247 genes by all kinase inhibitors Induced 306 genes
Enrichment Score: 12.63 Count P-Val Enrichment Score: 3.05 Count P-Val
membrane-enclosed lumen. 63 6.E-14 chromatin. 11 4.E-05
N nuclear lumen. 52 4.E-12 N chromosome. 13 3.E-03
Enrichment Score: 7.21 Enrichment Score: 2.48
rRNA processing. 12 1.E-08 Histone core. 7 8.E-06
T rRNA metabolic process. 12 2.E-08 N nucleosome. 6 5.E-04
Enrichment Score: 4.88 Enrichment Score: 2.40
regulation of phosphate metabolic process. 20 7.E-06 negative regulation of macromol. biosynth. process. 16 1.E-03
P regulation of phosphorylation. 18 5.E-05 T negative regulation of gene expression. 14 4.E-03
Enrichment Score: 4.02
regulation of phosphorylation. 18 5.E-05
P regulation of protein kinase activity. 15 8.E-05
Enrichment Score: 2.51
regulation of cell motion. 10 6.E-04
M positive regulation of cell migration. 6 5.E-03
Enrichment Score: 2.42
activation of caspase activity. 6 5.E-04
A positive regulation of caspase activity. 6 7.E-04
Enrichment Score: 2.13
Sprouty. 4 5.E-05
A negative regulation of MAP kinase activity. 5 9.E-04
Enrichment Score: 2.02
regulation of apoptosis. 19 9.E-03
regulation of programmed cell death. 19 1.E-02
Enrichment Score: 2.01
extracellular matrix binding. 4 4.E-03
laminin binding. 3 7.E-03
Enrichment Score: 2.00
apoptosis. 16 6.E-03
A programmed cell death. 16 7.E-03

The data pertain to the intersection of all lists in Fig. 3. The presentation is as in Table 2, except we kept 2 characteristic representative categories for each cluster. Enrichment score of 2.0 was used as the cut-off.