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. Author manuscript; available in PMC: 2014 Sep 3.
Published in final edited form as: Biochem J. 2009 Apr 15;419(2):467–474. doi: 10.1042/BJ20082090

Table 1. TTR screening with a library of phosphonate inhibitors.

Chemical structure of substrate-based phosphonate compounds that at 1 μM concentration yielded more than 80 % inhibition of TTR proteolytic activity.

Structure P1 P2
graphic file with name nihms619564t1.jpg Homolysine Proline
graphic file with name nihms619564t2.jpg Lysine Proline
graphic file with name nihms619564t3.jpg Lysine Proline
graphic file with name nihms619564t4.jpg Homolysine Proline
graphic file with name nihms619564t5.jpg Homolysine Proline
graphic file with name nihms619564t6.jpg Homolysine Proline
graphic file with name nihms619564t7.jpg Phenylalanine Leucine
graphic file with name nihms619564t8.jpg 4-(Amidine)-phenylalanine Proline