Table 1. Effect of fisetin on cisplatin-induced changes in renal antioxidants.

	Control	Fis	Cis	Cis+Fis-0.625 mg	Cis+Fis-1.25 mg
GSH levels	0.59±0.034	0.63±0.02	0.44±0.03$	0.67±0.05*	0.70±0.05*
GR activity	7.36±0.56	7.26±0.83	5.22±0.48$	7.10±0.31	8.49±0.95**
GST activity	15.98±0.79	16.46±1.33	7.42±1.47#	14.78±0.61**	18.69±2.04***
CAT activity	12.26±0.50	13.24±0.51	6.58±0.81#	7.87±0.38	11.10±0.93**
SOD activity	100.00±0.85	99.47±0.88	84.41±1.80#	96.4±1.02**	99.69±1.18***
NQO1 activity	127.81±5.97	132.38±4.20	89.62±18.22$	137.3±8.51**	152.86±4.49***
Vit C levels	0.82±0.05	1.37±0.13	0.38±0.08$	0.69±0.17	1.06±0.11**
TBARS levels	11.47±0.74	11.60±2.98	22.82±4.96$	10.79±2.46*	10.51±2.00*

All data were expressed as mean ± S.E.M. Where, Control, vehicle control (N = 7); Fis, fisetin alone treated group (N = 8); Cis, cisplatin alone treated group (N = 8); Cis+Fis-0.625 mg, fisetin (0.625 mg/kg) treated cisplatin-induced rats (N = 8); Cis+Fis-1.25 mg, fisetin (1.25 mg/kg) treated cisplatin-induced rats (N = 8); GSH, reduced glutathione (mg/g of tissue); GR, glutathione reductase (U/mg protein); GST, glutathione S-transferase (nmoles of CDNB conjugated/min/ml); CAT, catalase (U/mg protein); SOD, superoxide dismutase (% of control); NQO1, NAD (P) H: quinine oxidoreductase 1 (nmoles of DCIP reduced/min/mg protein); Vit C, vitamin C (mg/g of tissue); TBARS, thiobarbituric acid reactive substances (nmoles/g of tissue); CDNB, 1-chloro-2, 4-dinitrobenzene; DCIP, 2,6-dichlorophenolindophenol.

^$p<0.05,

^#p<0.01 vs control,

*p<0.05,

**p<0.01,

***p<0.001 vs Cis control.