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. 2014 Sep 3;9(9):e105628. doi: 10.1371/journal.pone.0105628

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© 2014 Blauenfeldt et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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ROC curve comparison of antigen-specific IP-10 mRNA expression and IP-10 and IFN-γ protein release. Cases comprised 30 TB patients and 13 LTBI persons and controls were 96 persons with no known exposure to M. tuberculosis. IP-10 gene expression was analysed from DBS and IP-10 and IFN-γ protein levels were analysed in plasma samples. AUCs was comparable at 0.88, 0.91 and 0.97 for IP-10 mRNA, IP-10 protein and QFT-TB respectively (p<0.0001). Cut offs were selected at the point rendering high sensitivity without compromised specificity.