Table 2. Accuracy of plasma M30 and serum ALT, AST and GGT for prediction of NAFLD.
Cut-off, U/L or IU/L* | Sensitivity, % | Specificity, % | PPV, % | NPV, % | |
Plasma M30 | 162 | 95.7 | 45.0 | 89.0 | 69.2 |
263 | 74.2 | 95.0 | 98.6 | 44.2 | |
278 | 67.7 | 100 | 100 | 40.0 | |
Serum ALT | 27 | 95.7 | 55.0 | 90.8 | 73.3 |
35 | 90.3 | 95.0 | 98.8 | 67.9 | |
47 | 73.1 | 100 | 100 | 44.4 | |
Serum AST | 21 | 92.5 | 55.0 | 90.5 | 61.1 |
33† | 65.6 | 100 | 100 | 38.5 | |
Serum GGT | 32 | 90.3 | 50.0 | 89.4 | 52.6 |
46 | 78.5 | 80.0 | 94.8 | 44.4 | |
55 | 62.4 | 95.0 | 98.3 | 35.2 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma glutamyl transpeptidase; NAFLD, non-alcoholic fatty liver disease; PPV, positive predictive value; NPV, negative predictive value.
* Cut-off with high sensitivity, highest overall accuracy and high specificity were presented.
Cut-off for highest overall accuracy and high specificity were the same.