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. 2014 Sep 3;9(9):e106101. doi: 10.1371/journal.pone.0106101

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Panel A: data represent model simulated (lines) and observed (circles) plasma concentrations of d-MPH (•) and l-MPH (○) after iv dosing with 10 mg MPH (n = 13) [4]; Panel B: data represent simulated (lines) and observed (triangles) urinary excretion of d-RA (▴) and l-RA (Δ) after iv dosing with 10 mg MPH (n = 9) [28]. Observed data were digitalized from graphs and are expressed as mean or mean ± SD based on the ability to digitalize: this applies to all figure legends unless otherwise specified.