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. 2014 Sep 3;9(9):e106101. doi: 10.1371/journal.pone.0106101

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Panel A: Data represent model simulated (lines) and observed (circles) plasma concentrations of d-MPH (•) and l-MPH (○) after oral dosing with10 mg MPH in boys with ADHD (n = 9) [7]; Panel B: Data as described for Panel A obtained after oral dosing with 10 mg MPH in boys with ADD (n = 5) [46]. Thin lines depict model simulations with MPH-specific model parameters set to adult values, and thick lines represent model predictions of plasma l-MPH concentrations with the calibrated children oral model, for which the value of K5lC describing gut metabolism of l-MPH was decreased from the adult value of 1.426 to 0.1 1/h/kg^0.75, while other MPH-specific model parameters were set to adult values.