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. 2014 Sep 3;9(9):e106101. doi: 10.1371/journal.pone.0106101

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Panel A: Data represent model simulated (line) and observed (circles) percentage of total dose excreted in urine as RA (•) after oral dosing with 20 mg MPH (n = 3) [20]; Panel B: Data represent model simulated (line) and observed (triangles) urinary excretion time courses of d-RA (▴) and l-RA (Δ) after oral dosing with 40 mg MPH (n = 9) [28].