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. 2014 Sep 3;9(9):e106101. doi: 10.1371/journal.pone.0106101

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Panel A: Data represent model simulated (lines) and observed (circles) plasma concentrations of d-MPH after oral dosing with 2.5 mg MPH in preschool-aged (•) (n = 1) and school-aged (○) (n = 2) children with ADHD [49]. Solid line represents simulations for preschool-aged children and dashed line represents simulations for school-aged children; Panel B: Data as described for Panel A obtained after oral dosing with 5 mg MPH in preschool-aged (•) (n = 8) and school-aged (○) (n = 2) children [49]; Panel C: Data as described for Panel A obtained after oral dosing with 7.5 mg MPH in preschool-aged (•) (n = 4) and school-aged (○) (n = 1) children [49]; Panel D: Data as described for Panel A obtained after oral dosing with 10 mg MPH in preschool-aged (•) (n = 1) and school-aged (○) (n = 4) children [49]; Panel E: Data represent model simulated (lines) and observed plasma concentration of d-MPH after oral dosing with 5 mg (×), 10 mg (○), and 20 mg (•) MPH in boys with ADHD (n = 31) [50].